人机验证

　　甲氧基聚乙二醇琥珀酰亚胺琥珀酸酯，在聚乙二醇键与NHS酯之间通过可降解的酯键连接，含有可降解键的线性NHS活性酯在药物缓释研发应用中应用非常广泛。

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　　References:

　　1. Xiong, Q., et al., Facile fabrication of reduction-responsive supramolecular nanoassemblies for co-delivery of doxorubicin and sorafenib towards hepatoma cells, Frontiers in pharmacology, 2018, 9, p.61.

　　2. Mastorakos, P., et al., Biodegradable brain-penetrating DNA nanocomplexes and their use to treat malignant brain tumors, Journal of Controlled Release, 2017, 262, P. 37-46.

　　3. Mastorakos, P., et al., Biodegradable DNA Nanoparticles that Provide Widespread Gene Delivery in the Brain, Small, 2015.

　　4. Jain, S., et al., Combinatorial bio-conjugation of gemcitabine and curcumin enables dual drug delivery with synergistic anticancer efficacy and reduced toxicity, RSC Adv., 2014, 4, 29193-29201.

　　5. Tesfay, M.Z., et al., PEGylation of vesicular stomatitis virus extends virus persistence in blood circulation of passively immunized mice. J Virol, 2013, 87(7): p. 3752-9.

　　6. Helgeson, L.A., et al, Mechanism of synergistic activation of Arp2/3 complex by cortactin and N-WASP, eLife, 2013, 2:e00884.

　　7. Depp, V., et al., Native protein-initiated ATRP: A viable and potentially superior alternative to PEGylation for stabilizing biologics, Acta Biomaterialia, 5(2), 2009, p: 560-569.

8.Narvaez-Ortiz, HY, et al., Unconcerted conformational changes in Arp2/3 complex integrate multiple activating signals to assemble functional actin networks. Current Biology. 2022.

9.Liu, C., et al., Functional modification of recombinant brain-derived neurotrophic factor and its protective effect against neurotoxicity, International Journal of Biological Macromolecules, 2024, V. 267, 2. Keywords: BDNF; TAT; PEG; Neurotoxicity; PD; SS-mPEG10000

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